Direct injection of protamine-protected mRNA: results of a phase 1/2 vaccination trial in metastatic melanoma patients - PubMedTwitterFacebookLinkedInGitHubTwitterSM-FacebookSM-Youtube

In mice, injection of messenger RNA (mRNA) coding for tumor-associated antigens can induce antitumor immune responses and therefore offers a broadly applicable immunotherapy approach. We injected intradermally protamine-stabilized mRNAs coding for Melan-A, Tyrosinase, gp100, Mage-A1, Mage-A3, and Su …